Cimicifuga Extract, Shengma Extract, Natural Botanical Extract, Cimifugin, Cimigenol, Anti-Inflammatory, Antibacterial, Heat-Clearing, Detoxifying, Pharmaceutical Grade
1. Product Description & Key Parameters
Cimicifuga Foetida L. Extract (Shengma Extract) is a natural botanical extract derived from the dried rhizomes of Cimicifuga foetida L., a perennial herb belonging to the Ranunculaceae family, commonly known as "Shengma" in traditional Chinese medicine. It has a long history of application in traditional Chinese medicine for its effects of relieving exterior syndrome and promoting eruption, clearing heat and detoxifying, and elevating yang to relieve collapse. The extract is produced through advanced water-ethanol mixed solvent extraction (ratio 60:40 v/v), purification, concentration and spray-drying processes, which effectively retain the plant's bioactive components. The final product is an off-white to pale yellow fine powder with a characteristic natural herbal odor, good flowability and no visible impurities, consistent with the typical appearance of Cimicifuga extract.
Core Parameters: - Assay Ratio: Customizable (5:1, 10:1, 20:1, 50:1), standard ratio 10:1; also available in 40%, 60%, 80% concentration specifications, and 10%-98% cimifugin concentrated specifications (HPLC ≥98% for high-purity cimifugin) - Active Ingredients: Cimifugin ≥2.0%, Cimigenol ≥1.5%, Isoferulic Acid ≥1.0%, Flavonoids ≥2.0%, Phenolic Acids ≥1.8% - Loss on Drying: ≤5.0% - Ash Content: ≤5.0% - Heavy Metals: ≤10ppm (Pb ≤2ppm, Cd ≤0.3ppm, As ≤1ppm, Hg ≤0.1ppm) - Microbial Limits: Total Aerobic Microbes ≤1000cfu/g, Yeast & Mold ≤100cfu/g, Coliforms: Negative, Salmonella: Negative - Solubility: ≥88% soluble in water (25ºC, 10% w/v) and ethanol (25ºC, 70% v/v); also soluble in methanol and DMSO, insoluble in petroleum ether - Particle Size: 80-100 mesh (standard), customizable 60-120 mesh - pH Value: 5.0-7.0 (1% w/v aqueous solution) - Shelf Life: 24 months (sealed, protected from light, moisture and high temperature; high-purity cimifugin recommended to be stored at 2-8ºC) - Packaging: 1kg/Aluminum Foil Bag, 5kg/Carton, 25kg/Fiber Drum (double plastic bag inside); small specifications (1g, 10g, 50g) available for high-purity samples - Certifications: ISO 9001, GMP, HACCP, Halal, Kosher, FDA (Food Grade, Pharmaceutical Grade), ECOCERT (Cosmetic Grade) - Detection Method: TLC (Thin Layer Chromatography), HPLC (for cimifugin, cimigenol and isoferulic acid content)
Cimicifuga Foetida L. Extract is rich in unique bioactive substances, mainly including cimifugin, cimigenol, isoferulic acid, flavonoids and phenolic acids, which are the key components responsible for its anti-inflammatory, antibacterial, heat-clearing and detoxifying activities. The product complies with international standards of food grade, cosmetic grade and pharmaceutical grade, ensuring high quality, safety and reliability for wide application in multiple fields. It also contains characteristic tetracyclic triterpene derivatives of Cimicifuga and furan chromone compounds, which are the main material basis for its traditional medicinal effects.
2. Features
- Natural and High-Quality Sourcing: Sourced from high-quality Cimicifuga foetida grown in pollution-free areas (main producing areas: Shaanxi, Sichuan, Qinghai, Yunnan, Henan of China), the raw materials are strictly selected-plump, intact dried rhizomes are cleaned, sliced and processed to ensure no impurities. No artificial colors, flavors or preservatives are added during the extraction process, making it a safe and natural botanical ingredient with a long history of traditional application. The raw materials are collected from under forests, slopes and streams, ensuring the natural active components of the plant are retained.
- Standardized Parameters and High Purity: Strictly controlled parameters (active ingredient content, particle size, solubility, etc.) ensure batch consistency. Precise extraction and purification technologies concentrate core active ingredients such as cimifugin and cimigenol, with high-purity specifications reaching HPLC ≥98%, resulting in high bioavailability that better exerts its functional effects, especially in anti-inflammatory and heat-clearing activities. The content of active ingredients can be accurately determined by HPLC method, ensuring product quality stability.
- Good Compatibility and Solubility: Consistent with parameter standards, it is easily soluble in water and ethanol, compatible with most ingredients in food, health products, cosmetics and pharmaceuticals without obvious incompatibility. It can be flexibly added to various product formulations without affecting the original texture, color and efficacy of the products. It also has good solubility in methanol and DMSO, which is suitable for the development of pharmaceutical preparations.
- Stable Physical and Chemical Properties: Under specified storage conditions, it maintains good stability, with no significant changes in the content of active ingredients (especially cimifugin and cimigenol). High-purity cimifugin needs to be stored at 2-8ºC to ensure stability. It is easy to store and transport, meeting the storage and transportation requirements of industrial production, especially for health care and pharmaceutical applications. The product has stable physical and chemical properties such as melting point and density, which is convenient for subsequent processing and application.
- Multi-functional and Versatile: It integrates multiple biological activities such as anti-inflammatory, antibacterial, heat-clearing, detoxifying, antipyretic and analgesic, with prominent effects on inflammation relief and heat-clearing detoxification. It also has effects on regulating the central nervous system, cardiovascular system and immune function, with strong adaptability in multiple fields and a wide range of application scenarios. Its unique bioactive components also have potential application value in inhibiting HIV and protecting liver function.
3. Functions
- Clearing Heat and Detoxifying: As a classic heat-clearing and detoxifying botanical extract, it can clear internal heat toxins, relieve symptoms such as sore throat, oral ulcers, skin eruptions and inflammation caused by heat accumulation, and help maintain the body's internal balance. It is a commonly used ingredient in traditional Chinese medicine for heat-clearing and detoxifying health care, and can also relieve discomfort caused by exogenous heat pathogens.
- Anti-Inflammatory and Analgesic: Cimifugin, cimigenol and isoferulic acid in the extract have obvious anti-inflammatory activity, which can inhibit the production of pro-inflammatory cytokines, inhibit iNOS and COX-2 expression by regulating JAK2/STAT3 signaling pathway, and relieve acute and chronic inflammation (especially skin inflammation, joint inflammation and respiratory inflammation). It also has a mild analgesic effect, helping to alleviate discomfort caused by inflammation and pain, and can inhibit acetic acid-induced writhing reaction in mice.
- Antibacterial and Antifungal: It has moderate antibacterial effect on Staphylococcus aureus, Staphylococcus albus and Neisseria catarrhalis, mild antibacterial effect on Pseudomonas aeruginosa, and inhibitory effect on Mycobacterium tuberculosis in test tubes. It also has inhibitory effect on fungi such as Trichophyton schoenleinii, Microsporum audouinii, Microsporum ferrugineum and Epidermophyton rubrum, helping to prevent mild infections. It can be used as a natural antibacterial and antifungal ingredient in related products.
- Antipyretic and Sedative: It can reduce the normal body temperature of rats, has antipyretic effect on fever in rats induced by typhoid and paratyphoid mixed vaccine, and can reduce animal activity, showing a certain sedative effect. It can also resist convulsions caused by camphor, and has a regulating effect on the central nervous system, helping to relieve fever and restlessness symptoms.
- Protecting Liver Function: The methanol extract of Cimicifuga and cimigenol xyloside can inhibit animal liver damage caused by carbon tetrachloride, reduce hepatocyte degeneration and necrosis, and reduce the increase of alanine aminotransferase, playing a role in protecting liver function. It is suitable for people who need liver health care, and can be used as a raw material for liver-protecting health products and drugs
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